Maternal history of autoimmune disease and later development of tourette syndrome in offspring

TitleMaternal history of autoimmune disease and later development of tourette syndrome in offspring
Publication TypeJournal Article
AuthorsDalsgaard, S., B. L. Waltoft, J. F. Leckman, and P. B. Mortensen
OBJECTIVE: In a nationwide prospective cohort study, we examined the possible association between maternal autoimmune disease (AD) and later diagnosis of Tourette syndrome (TS) in offspring. METHOD: Data from national Danish health registers identified a cohort consisting of all children born in Denmark between 1990 and 2007 (n = 1,116,255), followed prospectively from birth until 2011, date of TS diagnosis, death, or emigration/disappearance, whichever came first. The incidence rate ratio (IRR) of TS, dependent on whether or not the mother had a prior diagnosis of AD, was estimated by Poisson regression with 95% CIs and adjusted for age, calendar time, place of birth, maternal and paternal age, parental psychiatric diagnoses other than TS, and parental TS. RESULTS: The cohort contributed a total of 13,000,162 person years and 2,442 participants with a diagnosis of TS (414 females and 2,028 males). Prior maternal AD was found in 110 of the 2,442 children with TS, corresponding to an increased risk of TS, with an adjusted IRR of 1.22 (95% CI = 1.01-1.48). Maternal history of a prior AD increased the risk of TS in males, with an adjusted IRR of 1.29 (95% CI = 1.05-1.58), but not in females, with an adjusted IRR of 0.89 (95% CI = 0.52-1.52). CONCLUSION: Maternal AD was associated with a 29% increased incidence rate of TS in male offspring. This finding supports the hypothesis that neuroimmunological disorders may act as a component in the etiology of a subset of TS.
Title Maternal history of autoimmune disease and later development of tourette syndrome in offspring
Publication Title J Am Acad Child Adolesc Psychiatry
Publication Type Journal Article
Published Year 2015
Authors S. Dalsgaard; B.L. Waltoft; J.F. Leckman; P.B. Mortensen
Edition 2015/05/26
Accession Number 26004665
Number 6
ISBN Number 0890-8567
Grant List
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