@article {5878, title = {Maternal history of autoimmune disease and later development of tourette syndrome in offspring}, journal = {J Am Acad Child Adolesc Psychiatry}, volume = {54}, number = {6}, year = {2015}, note = {1527-5418
Dalsgaard, Soren
Waltoft, Berit L
Leckman, James F
Mortensen, Preben Bo
Journal Article
Research Support, Non-U.S. Gov{\textquoteright}t
United States
J Am Acad Child Adolesc Psychiatry. 2015 Jun;54(6):495-501.e1. doi: 10.1016/j.jaac.2015.03.008. Epub 2015 Mar 17.}, month = {Jun}, pages = {495-501.e1}, edition = {2015/05/26}, abstract = {OBJECTIVE: In a nationwide prospective cohort study, we examined the possible association between maternal autoimmune disease (AD) and later diagnosis of Tourette syndrome (TS) in offspring. METHOD: Data from national Danish health registers identified a cohort consisting of all children born in Denmark between 1990 and 2007 (n = 1,116,255), followed prospectively from birth until 2011, date of TS diagnosis, death, or emigration/disappearance, whichever came first. The incidence rate ratio (IRR) of TS, dependent on whether or not the mother had a prior diagnosis of AD, was estimated by Poisson regression with 95\% CIs and adjusted for age, calendar time, place of birth, maternal and paternal age, parental psychiatric diagnoses other than TS, and parental TS. RESULTS: The cohort contributed a total of 13,000,162 person years and 2,442 participants with a diagnosis of TS (414 females and 2,028 males). Prior maternal AD was found in 110 of the 2,442 children with TS, corresponding to an increased risk of TS, with an adjusted IRR of 1.22 (95\% CI = 1.01-1.48). Maternal history of a prior AD increased the risk of TS in males, with an adjusted IRR of 1.29 (95\% CI = 1.05-1.58), but not in females, with an adjusted IRR of 0.89 (95\% CI = 0.52-1.52). CONCLUSION: Maternal AD was associated with a 29\% increased incidence rate of TS in male offspring. This finding supports the hypothesis that neuroimmunological disorders may act as a component in the etiology of a subset of TS.}, keywords = {Adolescent, Adult, autoimmune disease, Autoimmune Diseases/*epidemiology, Child, cohort study, Denmark, Female, Humans, Incidence, Male, Mothers, neuroimmunology, Pregnancy, Prenatal Exposure Delayed Effects/*epidemiology, Prospective Studies, Registries, Regression Analysis, Sex Factors, tics, Tourette syndrome, Tourette Syndrome/diagnosis/*etiology, Young Adult}, isbn = {0890-8567}, doi = {10.1016/j.jaac.2015.03.008}, author = {Dalsgaard, S. and Waltoft, B. L. and Leckman, J. F. and Mortensen, P. B.} }