Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

TitleImplication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
Publication TypeJournal Article
AuthorsGapp, Katharina, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska, and Isabelle M. Mansuy
PubMed ID24728267
PubMed Central IDPMC4333222
Grant List092096 / / Wellcome Trust / United Kingdom
11832 / / Cancer Research UK / United Kingdom

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Title Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
Publication Title Nat Neurosci
Publication Type Journal Article
Published Year 2014
Authors K. Gapp; A. Jawaid; P. Sarkies; J. Bohacek; P. Pelczar; J. Prados; L. Farinelli; E. Miska; I.M. Mansuy
ISSN Number 1546-1726
PubMed ID 24728267
PubMed Central ID PMC4333222
Grant List
092096 Wellcome Trust United Kingdom
11832 Cancer Research UK United Kingdom

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