TY - JOUR T1 - Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. JF - Nat Neurosci Y1 - 2014 A1 - Gapp, Katharina A1 - Jawaid, Ali A1 - Sarkies, Peter A1 - Bohacek, Johannes A1 - Pelczar, Pawel A1 - Prados, Julien A1 - Farinelli, Laurent A1 - Miska, Eric A1 - Mansuy, Isabelle M KW - Animals KW - Animals, Newborn KW - Cell Line, Tumor KW - Dark Adaptation KW - Disease Models, Animal KW - Energy Intake KW - Female KW - Gene Expression Regulation KW - Male KW - Maternal Deprivation KW - Maze Learning KW - Mice KW - Mice, Inbred C57BL KW - MicroRNAs KW - Oocytes KW - Reaction Time KW - RNA, Small Interfering KW - RNA, Small Untranslated KW - Spermatozoa KW - Stress, Psychological AB -

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

VL - 17 IS - 5 ER -