<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Obikane, E.</style></author><author><style face="normal" font="default" size="100%">Shinozaki, T.</style></author><author><style face="normal" font="default" size="100%">Takagi, D.</style></author><author><style face="normal" font="default" size="100%">Kawakami, N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of childhood abuse on suicide-related behavior: Analysis using marginal structural models</style></title><secondary-title><style face="normal" font="default" size="100%">J Affect Disord</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Journal of affective disorders</style></alt-title><short-title><style face="normal" font="default" size="100%">Journal of affective disordersJournal of affective disorders</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Child Abuse</style></keyword><keyword><style  face="normal" font="default" size="100%">*Mental health, marginal structural model</style></keyword><keyword><style  face="normal" font="default" size="100%">*Suicidal behaviors</style></keyword><keyword><style  face="normal" font="default" size="100%">*Suicidal Ideation</style></keyword><keyword><style  face="normal" font="default" size="100%">*Suicide</style></keyword><keyword><style  face="normal" font="default" size="100%">Adaptation, Psychological</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult Survivors of Child Abuse/psychology/*statistics &amp; numerical data</style></keyword><keyword><style  face="normal" font="default" size="100%">Age of Onset</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Cross-Sectional Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mental Disorders/*epidemiology/psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Odds Ratio</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Suicide, Attempted/psychology/*statistics &amp; numerical data</style></keyword><keyword><style  face="normal" font="default" size="100%">Tokyo</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2018/03/17</style></edition><volume><style face="normal" font="default" size="100%">234</style></volume><pages><style face="normal" font="default" size="100%">224-230</style></pages><isbn><style face="normal" font="default" size="100%">0165-0327</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Childhood abuse is associated with adult suicidal behaviors, partially mediated by mental disorders. However, the direct effect of childhood abuse not mediated by mental disorders is uncertain because the same risk factors serve as mediators and confounders of mental disorders and suicidal behaviors. The aim of the study was to estimate the direct effect of childhood abuse not mediated by mental disorders on suicidal behaviors using marginal structural models. METHODS: We used cross-sectional data of Japanese adults in Tokyo and neighboring prefectures (The Japanese Study on Stratification, Health, Income, and Neighborhood). We developed a causal diagram of childhood abuse and suicidal behaviors, and defined exposures (childhood abuse), confounders (age, childhood social characteristics), mediators (mental disorders), risk factors (coping, smoking, alcohol consumption, education, physical health), and outcome (suicidal behaviors). We estimated the direct effect of childhood abuse according to sex using inverse-probability weighting at 2 points and compared to total and direct effects estimated by conventional regression models. RESULTS: Of 1776 male and 2016 female participants, childhood abuse showed significant total effects on suicidal behaviors. Physical abuse was associated with suicidal ideation (risk ratio: males 2.11 [95% confidence interval: 1.59-2.82], females 2.15 [1.69-2.72]), suicidal plan (risk ratio: males 2.18 [1.21-3.92], females 2.14 [1.24-3.74]), and suicidal attempt (risk ratio: males 2.11 [1.14-5.10], females 4.79 [2.93-7.83]) through direct effect. LIMITATIONS: Childhood abuse was measured according to self-report of the past experiences. CONCLUSIONS: Our study suggests that childhood abuse is associated with adult suicidal behaviors through direct effects not mediated by mental disorders.</style></abstract><accession-num><style face="normal" font="default" size="100%">29547815</style></accession-num><notes><style face="normal" font="default" size="100%">1573-2517&lt;br/&gt;Obikane, Erika&lt;br/&gt;Shinozaki, Tomohiro&lt;br/&gt;Takagi, Daisuke&lt;br/&gt;Kawakami, Norito&lt;br/&gt;Journal Article&lt;br/&gt;Research Support, Non-U.S. Gov't&lt;br/&gt;Netherlands&lt;br/&gt;J Affect Disord. 2018 Jul;234:224-230. doi: 10.1016/j.jad.2018.02.034. Epub 2018 Feb 22.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: erika-kr@nifty.com.&lt;br/&gt;Department of Biostatistics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.&lt;br/&gt;Department of Health and Social Behavior, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.&lt;br/&gt;Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>