<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Stevens, H. E.</style></author><author><style face="normal" font="default" size="100%">Leckman, J. F.</style></author><author><style face="normal" font="default" size="100%">Coplan, J. D.</style></author><author><style face="normal" font="default" size="100%">Suomi, S. J.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk and resilience: early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes</style></title><secondary-title><style face="normal" font="default" size="100%">J Am Acad Child Adolesc Psychiatry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Mother-Child Relations</style></keyword><keyword><style  face="normal" font="default" size="100%">*Neurophysiology</style></keyword><keyword><style  face="normal" font="default" size="100%">*Resilience, Psychological</style></keyword><keyword><style  face="normal" font="default" size="100%">*Stress, Psychological</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent Behavior/physiology/*psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child Behavior/physiology/*psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child Development/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child Rearing/*psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaca</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurotransmitter Agents/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Social Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Social Environment</style></keyword><keyword><style  face="normal" font="default" size="100%">Temperament/physiology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Feb</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">48</style></volume><pages><style face="normal" font="default" size="100%">114-27</style></pages><isbn><style face="normal" font="default" size="100%">1527-5418 (Electronic)&lt;br/&gt;0890-8567 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE: To review the contributions of research on nonhuman primates, specifically macaque monkeys, to the understanding of early social stress and its effects on behavior and neurophysiology. METHOD: Review and synthesis of two bodies of work on macaque monkeys and early social manipulation: peer rearing and variable foraging demands. The literature was searched with Medline using key terms macaque, variable foraging, and peer rearing. The reference lists of these articles were also used to generate potential studies for review. RESULTS: Nonhuman primate macaques show similarities to humans in their social development and functioning. Peer rearing of young macaques and rearing of young macaques with mothers experiencing variable foraging conditions both result in increased anxious, impulsive, and aggressive temperament and behavior; more reactive stress physiology; altered neurotransmitter functioning; and immune and metabolic changes. Functional variants of specific genes that code for neuromodulators are mediators of these effects. CONCLUSIONS: Disrupted social relations during macaque rearing contribute to the risk for developing emotional and neurophysiological disturbance. In the face of such disruption, certain genotypes contribute to resilience. This can be alternately stated that, for animals of high-risk genotypes, resilience is conferred by quality relationships during rearing. This interaction of genetics with early social environment also applies to child mental health, implicating biological mediators identified in macaques as contributing to more complex outcomes in humans.</style></abstract><accession-num><style face="normal" font="default" size="100%">19127170</style></accession-num><notes><style face="normal" font="default" size="100%">Stevens, Hanna E&lt;br/&gt;Leckman, James F&lt;br/&gt;Coplan, Jeremy D&lt;br/&gt;Suomi, Stephen J&lt;br/&gt;eng&lt;br/&gt;Research Support, Non-U.S. Gov't&lt;br/&gt;Review&lt;br/&gt;2009/01/08 09:00&lt;br/&gt;J Am Acad Child Adolesc Psychiatry. 2009 Feb;48(2):114-27. doi: 10.1097/CHI.0b013e318193064c.</style></notes><auth-address><style face="normal" font="default" size="100%">230 S. Frontage Rd., Yale Child Study Center, New Haven, CT 06520, USA. hanna.stevens@yale.edu</style></auth-address></record></records></xml>