<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deaton, A. M.</style></author><author><style face="normal" font="default" size="100%">Bird, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">CpG islands and the regulation of transcription</style></title><secondary-title><style face="normal" font="default" size="100%">Genes Dev</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromatin/chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">CpG Islands/genetics/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Methylation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Silencing</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycomb-Group Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Promoter Regions, Genetic/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Repressor Proteins/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcription Initiation Site</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 15</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://genesdev.cshlp.org/content/25/10/1010</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">10</style></number><volume><style face="normal" font="default" size="100%">25</style></volume><pages><style face="normal" font="default" size="100%">1010-22</style></pages><isbn><style face="normal" font="default" size="100%">1549-5477 (Electronic)&lt;br/&gt;0890-9369 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters. Shared DNA sequence features adapt CGIs for promoter function by destabilizing nucleosomes and attracting proteins that create a transcriptionally permissive chromatin state. Silencing of CGI promoters is achieved through dense CpG methylation or polycomb recruitment, again using their distinctive DNA sequence composition. CGIs are therefore generically equipped to influence local chromatin structure and simplify regulation of gene activity.</style></abstract><accession-num><style face="normal" font="default" size="100%">21576262</style></accession-num><notes><style face="normal" font="default" size="100%">Deaton, Aimee M&lt;br/&gt;Bird, Adrian&lt;br/&gt;eng&lt;br/&gt;Cancer Research UK/United Kingdom&lt;br/&gt;Medical Research Council/United Kingdom&lt;br/&gt;Wellcome Trust/United Kingdom&lt;br/&gt;Research Support, Non-U.S. Gov't&lt;br/&gt;Review&lt;br/&gt;2011/05/18 06:00&lt;br/&gt;Genes Dev. 2011 May 15;25(10):1010-22. doi: 10.1101/gad.2037511.</style></notes><custom2><style face="normal" font="default" size="100%">PMC3093116</style></custom2><auth-address><style face="normal" font="default" size="100%">The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.</style></auth-address></record></records></xml>