<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">de Quervain, D. J.</style></author><author><style face="normal" font="default" size="100%">Kolassa, I. T.</style></author><author><style face="normal" font="default" size="100%">Ackermann, S.</style></author><author><style face="normal" font="default" size="100%">Aerni, A.</style></author><author><style face="normal" font="default" size="100%">Boesiger, P.</style></author><author><style face="normal" font="default" size="100%">Demougin, P.</style></author><author><style face="normal" font="default" size="100%">Elbert, T.</style></author><author><style face="normal" font="default" size="100%">Ertl, V.</style></author><author><style face="normal" font="default" size="100%">Gschwind, L.</style></author><author><style face="normal" font="default" size="100%">Hadziselimovic, N.</style></author><author><style face="normal" font="default" size="100%">Hanser, E.</style></author><author><style face="normal" font="default" size="100%">Heck, A.</style></author><author><style face="normal" font="default" size="100%">Hieber, P.</style></author><author><style face="normal" font="default" size="100%">Huynh, K. D.</style></author><author><style face="normal" font="default" size="100%">Klarhofer, M.</style></author><author><style face="normal" font="default" size="100%">Luechinger, R.</style></author><author><style face="normal" font="default" size="100%">Rasch, B.</style></author><author><style face="normal" font="default" size="100%">Scheffler, K.</style></author><author><style face="normal" font="default" size="100%">Spalek, K.</style></author><author><style face="normal" font="default" size="100%">Stippich, C.</style></author><author><style face="normal" font="default" size="100%">Vogler, C.</style></author><author><style face="normal" font="default" size="100%">Vukojevic, V.</style></author><author><style face="normal" font="default" size="100%">Stetak, A.</style></author><author><style face="normal" font="default" size="100%">Papassotiropoulos, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">PKCalpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors</style></title><secondary-title><style face="normal" font="default" size="100%">Proc Natl Acad Sci U S AProc Natl Acad Sci U S AProceedings of the National Academy of Sciences of the United States of America</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Proceedings of the National Academy of Sciences of the United States of America</style></alt-title><short-title><style face="normal" font="default" size="100%">P Natl Acad Sci USA</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain/pathology/physiopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Homicide/psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnetic Resonance Imaging</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Mental Recall/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Photic Stimulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Kinase C-alpha/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Psychomotor Performance/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Rwanda/ethnology</style></keyword><keyword><style  face="normal" font="default" size="100%">Stress Disorders, Post-Traumatic/*genetics/*physiopathology/psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Survivors/psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Uganda</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 29</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">22</style></number><edition><style face="normal" font="default" size="100%">2012/05/16</style></edition><volume><style face="normal" font="default" size="100%">109</style></volume><pages><style face="normal" font="default" size="100%">8746-51</style></pages><isbn><style face="normal" font="default" size="100%">0027-8424</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Strong memory of a traumatic event is thought to contribute to the development and symptoms of posttraumatic stress disorder (PTSD). Therefore, a genetic predisposition to build strong memories could lead to increased risk for PTSD after a traumatic event. Here we show that genetic variability of the gene encoding PKCalpha (PRKCA) was associated with memory capacity--including aversive memory--in nontraumatized subjects of European descent. This finding was replicated in an independent sample of nontraumatized subjects, who additionally underwent functional magnetic resonance imaging (fMRI). fMRI analysis revealed PRKCA genotype-dependent brain activation differences during successful encoding of aversive information. Further, the identified genetic variant was also related to traumatic memory and to the risk for PTSD in heavily traumatized survivors of the Rwandan genocide. Our results indicate a role for PKCalpha in memory and suggest a genetic link between memory and the risk for PTSD.</style></abstract><accession-num><style face="normal" font="default" size="100%">22586106</style></accession-num><notes><style face="normal" font="default" size="100%">1091-6490&lt;br/&gt;de Quervain, Dominique J-F&lt;br/&gt;Kolassa, Iris-Tatjana&lt;br/&gt;Ackermann, Sandra&lt;br/&gt;Aerni, Amanda&lt;br/&gt;Boesiger, Peter&lt;br/&gt;Demougin, Philippe&lt;br/&gt;Elbert, Thomas&lt;br/&gt;Ertl, Verena&lt;br/&gt;Gschwind, Leo&lt;br/&gt;Hadziselimovic, Nils&lt;br/&gt;Hanser, Edveena&lt;br/&gt;Heck, Angela&lt;br/&gt;Hieber, Petra&lt;br/&gt;Huynh, Kim-Dung&lt;br/&gt;Klarhofer, Markus&lt;br/&gt;Luechinger, Roger&lt;br/&gt;Rasch, Bjorn&lt;br/&gt;Scheffler, Klaus&lt;br/&gt;Spalek, Klara&lt;br/&gt;Stippich, Christoph&lt;br/&gt;Vogler, Christian&lt;br/&gt;Vukojevic, Vanja&lt;br/&gt;Stetak, Attila&lt;br/&gt;Papassotiropoulos, Andreas&lt;br/&gt;Journal Article&lt;br/&gt;Randomized Controlled Trial&lt;br/&gt;Research Support, Non-U.S. Gov't&lt;br/&gt;United States&lt;br/&gt;Proc Natl Acad Sci U S A. 2012 May 29;109(22):8746-51. doi: 10.1073/pnas.1200857109. Epub 2012 May 14.</style></notes><custom2><style face="normal" font="default" size="100%">PMC3365172</style></custom2><auth-address><style face="normal" font="default" size="100%">Division of Cognitive Neuroscience, Department of Psychology, University of Basel, 4055 Basel, Switzerland. dominique.dequervain@unibas.ch</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>