TY - JOUR T1 - Epigenetics and the environmental regulation of the genome and its function. JF - Annu Rev Psychol Y1 - 2010 A1 - Zhang, Tie-Yuan A1 - Meaney, Michael J KW - Animals KW - DNA Methylation KW - Environment KW - Epigenesis, Genetic KW - Gene Expression Regulation, Developmental KW - Genome KW - Genomic Imprinting KW - Humans KW - Maternal Behavior AB -

There are numerous examples in psychology and other disciplines of the enduring effects of early experience on neural function. In this article, we review the emerging evidence for epigenetics as a candidate mechanism for these effects. Epigenetics refers to functionally relevant modifications to the genome that do not involve a change in nucleotide sequence. Such modifications include chemical marks that regulate the transcription of the genome. There is now evidence that environmental events can directly modify the epigenetic state of the genome. Thus studies with rodent models suggest that during both early development and in adult life, environmental signals can activate intracellular pathways that directly remodel the "epigenome," leading to changes in gene expression and neural function. These studies define a biological basis for the interplay between environmental signals and the genome in the regulation of individual differences in behavior, cognition, and physiology.

VL - 61 ER -