@article {4611, title = {Gene variants associated with antisocial behaviour: a latent variable approach}, journal = {J Child Psychol Psychiatry}, volume = {54}, number = {10}, year = {2013}, note = {Bentley, Mary Jane
Lin, Haiqun
Fernandez, Thomas V
Lee, Maria
Yrigollen, Carolyn M
Pakstis, Andrew J
Katsovich, Liliya
Olds, David L
Grigorenko, Elena L
Leckman, James F
eng
R25 MH077823/MH/NIMH NIH HHS/
R01DA021624/DA/NIDA NIH HHS/
T32MH018268/MH/NIMH NIH HHS/
T32 MH018268/MH/NIMH NIH HHS/
R01DA216240/DA/NIDA NIH HHS/
R01 DA021624/DA/NIDA NIH HHS/
Research Support, N.I.H., Extramural
England
2013/07/05 06:00
J Child Psychol Psychiatry. 2013 Oct;54(10):1074-85. doi: 10.1111/jcpp.12109. Epub 2013 Jul 3.}, month = {Oct}, pages = {1074-85}, abstract = {OBJECTIVE: The aim of this study was to determine if a latent variable approach might be useful in identifying shared variance across genetic risk alleles that is associated with antisocial behaviour at age 15 years. METHODS: Using a conventional latent variable approach, we derived an antisocial phenotype in 328 adolescents utilizing data from a 15-year follow-up of a randomized trial of a prenatal and infancy nurse-home visitation programme in Elmira, New York. We then investigated, via a novel latent variable approach, 450 informative genetic polymorphisms in 71 genes previously associated with antisocial behaviour, drug use, affiliative behaviours and stress response in 241 consenting individuals for whom DNA was available. Haplotype and Pathway analyses were also performed. RESULTS: Eight single-nucleotide polymorphisms (SNPs) from eight genes contributed to the latent genetic variable that in turn accounted for 16.0\% of the variance within the latent antisocial phenotype. The number of risk alleles was linearly related to the latent antisocial variable scores. Haplotypes that included the putative risk alleles for all eight genes were also associated with higher latent antisocial variable scores. In addition, 33 SNPs from 63 of the remaining genes were also significant when added to the final model. Many of these genes interact on a molecular level, forming molecular networks. The results support a role for genes related to dopamine, norepinephrine, serotonin, glutamate, opioid and cholinergic signalling as well as stress response pathways in mediating susceptibility to antisocial behaviour. CONCLUSIONS: This preliminary study supports use of relevant behavioural indicators and latent variable approaches to study the potential {\textquoteright}co-action{\textquoteright} of gene variants associated with antisocial behaviour. It also underscores the cumulative relevance of common genetic variants for understanding the aetiology of complex behaviour. If replicated in future studies, this approach may allow the identification of a {\textquoteright}shared{\textquoteright} variance across genetic risk alleles associated with complex neuropsychiatric dimensional phenotypes using relatively small numbers of well-characterized research participants.}, keywords = {Adolescent, Adolescent Behavior/*physiology, Antisocial behaviour, Antisocial Personality Disorder/*genetics, co-action of gene variants, Female, Follow-Up Studies, Genetic Predisposition to Disease/*genetics, Genotype, Genotyping Techniques, Humans, latent variable analysis, Male, Models, Genetic, Phenotype, Pilot Projects, Polymorphism, Single Nucleotide/*genetics, Randomized Controlled Trials as Topic, Reaction Time/genetics, shared variance}, isbn = {1469-7610 (Electronic)
0021-9630 (Linking)}, doi = {10.1111/jcpp.12109}, author = {Bentley, M. J. and Lin, H. and Fernandez, T. V. and Lee, M. and Yrigollen, C. M. and Pakstis, A. J. and Katsovich, L. and Olds, D. L. and Grigorenko, E. L. and Leckman, J. F.} }