@article {438,
	title = {Social disadvantage, genetic sensitivity, and children{\textquoteright}s telomere length.},
	journal = {Proc Natl Acad Sci U S A},
	volume = {111},
	year = {2014},
	month = {2014 Apr 22},
	pages = {5944-9},
	abstract = {<p>Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts, including disadvantaged social standing and depression. We use data from 40, 9-y-old boys participating in the Fragile Families and Child Wellbeing Study to extend this observation to African American children. We report that exposure to disadvantaged environments is associated with reduced TL by age 9 y. We document significant associations between low income, low maternal education, unstable family structure, and harsh parenting and TL. These effects were moderated by genetic variants in serotonergic and dopaminergic pathways. Consistent with the differential susceptibility hypothesis, subjects with the highest genetic sensitivity scores had the shortest TL when exposed to disadvantaged social environments and the longest TL when exposed to advantaged environments.</p>
},
	keywords = {Adult, Child, Dopamine, Gene-Environment Interaction, Humans, Male, Regression Analysis, Serotonin, Signal Transduction, Social Environment, Telomere Homeostasis, Vulnerable Populations},
	issn = {1091-6490},
	doi = {10.1073/pnas.1404293111},
	author = {Mitchell, Colter and Hobcraft, John and McLanahan, Sara S and Siegel, Susan Rutherford and Berg, Arthur and Brooks-Gunn, Jeanne and Garfinkel, Irwin and Notterman, Daniel}
}
