@article {2801, title = {PKCalpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors}, journal = {Proc Natl Acad Sci U S AProc Natl Acad Sci U S AProceedings of the National Academy of Sciences of the United States of America}, volume = {109}, number = {22}, year = {2012}, note = {1091-6490
de Quervain, Dominique J-F
Kolassa, Iris-Tatjana
Ackermann, Sandra
Aerni, Amanda
Boesiger, Peter
Demougin, Philippe
Elbert, Thomas
Ertl, Verena
Gschwind, Leo
Hadziselimovic, Nils
Hanser, Edveena
Heck, Angela
Hieber, Petra
Huynh, Kim-Dung
Klarhofer, Markus
Luechinger, Roger
Rasch, Bjorn
Scheffler, Klaus
Spalek, Klara
Stippich, Christoph
Vogler, Christian
Vukojevic, Vanja
Stetak, Attila
Papassotiropoulos, Andreas
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov{\textquoteright}t
United States
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8746-51. doi: 10.1073/pnas.1200857109. Epub 2012 May 14.}, month = {May 29}, pages = {8746-51}, edition = {2012/05/16}, abstract = {Strong memory of a traumatic event is thought to contribute to the development and symptoms of posttraumatic stress disorder (PTSD). Therefore, a genetic predisposition to build strong memories could lead to increased risk for PTSD after a traumatic event. Here we show that genetic variability of the gene encoding PKCalpha (PRKCA) was associated with memory capacity--including aversive memory--in nontraumatized subjects of European descent. This finding was replicated in an independent sample of nontraumatized subjects, who additionally underwent functional magnetic resonance imaging (fMRI). fMRI analysis revealed PRKCA genotype-dependent brain activation differences during successful encoding of aversive information. Further, the identified genetic variant was also related to traumatic memory and to the risk for PTSD in heavily traumatized survivors of the Rwandan genocide. Our results indicate a role for PKCalpha in memory and suggest a genetic link between memory and the risk for PTSD.}, keywords = {*Polymorphism, Single Nucleotide, Adolescent, Adult, Aged, Brain/pathology/physiopathology, Female, Genotype, Homicide/psychology, Humans, Magnetic Resonance Imaging, Male, Memory/*physiology, Mental Recall/physiology, Middle Aged, Photic Stimulation, Protein Kinase C-alpha/*genetics, Psychomotor Performance/physiology, Risk Factors, Rwanda/ethnology, Stress Disorders, Post-Traumatic/*genetics/*physiopathology/psychology, Survivors/psychology, Uganda, Young Adult}, isbn = {0027-8424}, doi = {https://doi.org/10.1073/pnas.1200857109}, author = {de Quervain, D. J. and Kolassa, I. T. and Ackermann, S. and Aerni, A. and Boesiger, P. and Demougin, P. and Elbert, T. and Ertl, V. and Gschwind, L. and Hadziselimovic, N. and Hanser, E. and Heck, A. and Hieber, P. and Huynh, K. D. and Klarhofer, M. and Luechinger, R. and Rasch, B. and Scheffler, K. and Spalek, K. and Stippich, C. and Vogler, C. and Vukojevic, V. and Stetak, A. and Papassotiropoulos, A.} }